Ornamental shells from the war memorial were uprooted and private tombstones were smashed.
Police are now investigating the incident, which Sgt Jeff Zammit has described as “pathetic.”
All the windows of the bookstore were targeted by inscriptions, such as "Christianity is a successful sect".
Catholic churches represent the religious symbol that is the most often targeted by vandals.
France remains the European country in which the rise of anti-Christian vandalism is the most significant.
These two statues have already been targeted several times. In 2013, vandals cut off the arm of the statue depicting Reagan.
"We can't allow a handful of people to destroy religious freedom" underlined Louisiana Senator John Kennedy.
The Saint-Pierre-de-La Vernière church has been classified as a heritage building since 1992.
Italian Catholics would like to establish a permanent "observatory for religious freedom" in their country.